„DON“ compounds


These potent molecules are side-chain modified peptides. The electrophilic “DON” group replaces the substrate glutamine. The active site cysteinyl residue attacks the carbonyl group (1). The subsequent reaction leads to the release of nitrogen (2) and the concomitant irreversible alkylation at the active site of the transglutaminases (3).

 
DON comppound reaction mechanism

Zedira developed molecules frequently used in scientific literature. 

 
  • Z-DON (Z006; Z-DON-Val-Pro-Leu-OMe) Z-DON is a very potent and specific blocker of tissue transglutaminase (IC50 about 0.02 μM) and is membrane permeable.
  • Boc-DON (B003; Boc-DON-Gln-Ile-Val-OMe) Boc-DON is a potent and specific blocker of tissue transglutaminase (IC50 about 0.3 μM) and is not membrane permeable.

Art. No. Name Unit Price
B003 Boc-DON-Gln-Ile-Val-OMe, Boc-DON
10 mg 400 €
Z006 Z-DON-Val-Pro-Leu-OMe, "Z-DON"
10 mg 425 €
Z011 Z-(D)-DON-Val-Pro-Leu-OMe, Z-(D)-DON
10 mg 450 €

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