Michael acceptor
peptidomimetics

Biotin-Ahx-MA-QPL-OMe

Quantity Unit Price Status
10 mg 500 € On request
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Documents
Art. No.
B015
Molecular Formula
C41H66N8O11S
Molecular Weight
879.07
Purity by HPLC
>95 % (214 nm)
Appearance
Off-white solid
Solubility
50 µM in 0.5% (v/v) DMSO / aqueous buffers
Pre-dissolve e.g. 3.19 mg (3.63 µmol) in 363 µl DMSO - dilute e.g. 10 µl of that stock solution (10 mM) with 1990 µl aqueous buffer (1:200) to obtain a 50 µM solution. DMSO stock solutions can be stored at -20°C for at least 6 months. To avoid too many freeze-thaw cycles, we strongly recommend storage of aliquots
Application
Site specific irreversible inhibitor of tissue transglutaminase. Peptidic inhibitor containing an electrophilic Michael acceptor (MA) warhead.
Biotinyl-analogon to Z013 (Z-MA-QPL-OMe)
Efficacy
TG2: IC50 =122 nM (Transglutaminase Assay Kit T036; Zedira, Germany)
TG6: IC50 =2,207 nM (Transglutaminase Assay Kit T036; Zedira, Germany)
Storage
Store at -20°C, desiccate
Note
INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.

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