Michael acceptor
peptidomimetics

Z-MA-QPL-OMe

Quantity Unit Price Status
10 mg 500 € Available
Documents
Art. No.
Z013
Synonym
ZED754
Molecular Formula
C34H49N5O10
Molecular Weight
687.78
Purity by HPLC
>95 % (214 nm)
Appearance
Off-white solid
Solubility
200 μM in 2% (v/v) DMSO / aqueous buffers.
Pre-dissolve e.g. 1.30 mg (1.89 μmol) in 189 μl DMSO - dilute e.g. 20 μl of that stock solution (10 mM) with 980 μl buffer to obtain a 200 μM solution.
DMSO stock solutions can be stored at -20°C for at least 6 months. To avoid too many freeze-thaw cycles, we strongly recommend storage of aliquots.
Application
Site specific irreversible inhibitor of tissue transglutaminase. Peptidic inhibitor containing an electrophilic Michael acceptor (MA) warhead.
Cbz-analogon (Carboxybenzyl, Z) to B015 (Biotin-Ahx-MA-QPL-OMe).
Efficacy
TG2: IC50 = 224 nM (Transglutaminase Assay Kit T036; Zedira, Germany)
TG6: IC50 = 486 nM (Transglutaminase Assay Kit T036; Zedira, Germany)
Storage
Store at -20°C, desiccate
Reference(s)
Protein Data Bank (PDB) entry: 3S3P
Further please refer to:
“Inhibitors of transglutaminase 2: A therapeutic option in celiac disease”
(http://zedira.com/data/newsletter/newsletter_20080902.pdf)
Note
INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.

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