Transglutaminase inhibitors


Transglutaminases are involved in a multitude of physiological processes. One way to explore these processes is to use specific inhibitors. In addition to naturally occurring inhibitors such as the protein tridegin, rationally designed synthetic, small molecule inhibitors such as Z-DON (Z006) will be of immeasurable help to scientists wishing to decipher the enigmatic roles of individual transglutaminases.

In the following section, Zedira’s range of transglutaminase inhibitors is introduced with a special focus on their respective mechanism of action:


“DON” compounds (6-diazo-5-oxo-L-norleucine containing peptides)
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2-[(2-oxo-propyl)thio]imidazolium derivatives
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Naturally occurring inhibitors
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Michael acceptor peptidomimetics
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Lysine analogues - chloromethyl ketones
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Keillor Inhibitors (Acrylamide derivatives)
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Unknown mode of inhibiton
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Products

  • Zedira offers a huge portfolio of reliable specialist transglutaminase related products meant to catalyze research and development, both in academia and industry.

News  

  • Zedira publication - Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease
  • Dr. Falk Pharma and Zedira announce start of the phase 2b real-life study of ZED1227 for the treatment of Celiac Disease
  • imageDr. Falk Pharma and Zedira announce successful completion of the phase 2a proof-of-concept study of ZED1227 for the treatment of Celiac Disease
  • imageDr. Falk Pharma und Zedira verkünden den erfolgreichen Abschluss der Phase 2a-Studie mit ZED1227 zur Behandlung von Zöliakie
  • imageReversibly acting transglutaminase 2 inhibitors: drug candidates for the treatment of fibrosis
  • imagePress release: Zedira announces ISO 9001:2015 certification

Blog  

  • DZG Aktuell: „Aufruf zur Teilnahme an einer weiteren Wirksamkeitsstudie mit dem Studienmedikament ZED1227“
  • imageDesign of Oral FXIIIa Blockers as Safer Anticoagulants – Mission Impossible?
  • imageMicrobial transglutaminase (MTG) enables efficient and site-specific conjugation to native antibodies without the need of antibody engineering

Events  

  • Canceled: Gordon Research Conference - Transglutaminases in Human Disease Processes

    12.06.2022 - 17.06.2022
    Mount Snow, USA

  • 19th International Celiac Disease Symposium

    19.10.2022 - 22.10.2022
    Sorrento, Italy