22. January 2021

Clinical Validation of an Automated Fluorogenic FXIII Activity Assay

Zedira kits


Zedira Logo                                                                                                                                                                     Transglutaminase-Newsletter | January 2021



Dear Transglutaminase researchers,

On January 20th 2021, Technoclone (Vienna, Austria) and Zedira published the second joint paper entitled "Clinical Validation of an Automated Fluorogenic Factor XIII Activity Assay Based on Isopeptidase Activity".

The paper was published in the International Journal of Molecular Sciences as part of the Special Issue Fibrinogen/Fibrin, Factor XIII and Fibrinolysis in Diseases. The accurate, rapid, and precise assay is meant to improve routine diagnostics and therefore should help patients, physicians, and researchers.

At Zedira, we are scientists at heart. Cutting edge science and technology are mandatory for entrepreneurial success in the biotech business. Besides tissue transglutaminase, our research focused on coagulation factor XIII for already about two decades by now.
Our proprietary compound ZED3197 showed the proof-of-principle of “safe” anticoagulation therapy. Specific inhibition of FXIIIa allows unprecedented intervention in the coagulation cascade (published in Journal of Thrombosis and Haemostasis as Open access paper).

We are happy to share with you our exclusive products to support your esteemed research & development. Please find bellow a collection of our most important FXIII related tools.


FXIII

Art. No.NameUnitPrice

T027

Human blood coagulation Factor XIII-A2, recombinant
(hFXIII, A subunit, recombinantly produced in insect cells)

200 µg370 €
T070

Human Factor XIIIa, Thrombin activated
(hFXIIIa, recombinantly produced in insect cells)


200 µg520 €
T050

Human blood coagulation Factor XIII B subunit
(hFXIII B, F13B, recombinantly produced in insect cells)

200 µg370 €

Assays and Substrates

Art. No.NameUnitPrice

A101

FXIII-Assay Substance,
Abz-NE(CAD-DNP)EQVSPLTLLK-OH

10 mg
520 €
F001

FXIII-Assay Kit
(ready to use, contains A101 and thrombin)

1 Kit
575 €

Inhibitors

Art. No.NameUnitPrice

T101

1,3,4,5-Tetramethyl-2[(2-oxo-propyl)thio] imidazolium chloride

10 mg
480 €
A108

Ac-(D)-Asp-MA-Nle-Nle-Leu-Pro-Trp-Pro-OH
(Synonym ZED1301, site specific irreversible inhibitor of FXIII)

5 mg
480 €


NEW

Art. No.NameUnitPrice

T222

Human Alpha Thrombin, recombinant

100 NIH Units185 €


Antibodies

Art. No.NameUnitPrice

A016

Polyclonal antibody to human factor XIII (A-subunit)

500 µg
365 €
A032

FITC-labeled polyclonal antibody to human factor XIII (A-subunit)

200 µg
395 €
A074Monoclonal antibody to human factor XIII (Activation Peptide, clone XTG09)

200 µg365 €
A077
FITC-labeled polyclonal antibody to human factor XIII (B-subunit)
 
200 µg365 €
A076

"DD-XLink-mab"
Monoclonal antibody against crosslinked fibrin ("D-dimer")
100 µg
365 €




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