2-[(2-oxopropyl)thio]
imidazolium derivates

1,3-Dimethyl-4,5-diphenyl-2-[(2-oxopropyl)thio]imidazolium trifluorosulfonic acid salt

Quantity Unit Price Status
10 mg 550 € Available
Documents
Art. No.
D004
Synonym
"L-683.685"; 1,3-Dimethyl-2-(2-oxopropylthio)-4,5-diphenyl-1H-imidazol-3-ium trifluoromethanesulfonate
Molecular Formula
C21H21F3N2O4S2 (free cation: C20H21N2OS+)
Molecular Weight
486.53 (free cation: 337.46)
Purity
> 95% (NMR)
Appearance
off white solid
Solubility
Pre-dissolve e.g. 2.02 mg in 207.6 μl DMSO to obtain a 20 mM stock solution - dilute 20 μl of that stock solution with 980 μl buffer (e.g. 50 mM TRIS-HCl, pH 7.5) to obtain a 400 μM solution
Application
Inhibitior for transglutaminase. Cell-permeable [3]
The molecule was developed to block coagulation factor XIIIa, however the compound inhibits tissue transglutaminase as well. Both enzymes are inhibited with an IC50 of about 0.35 μM.
Storage
Store at -20°C
Reference(s)
[1] Lorand et al., Exp. Eye Res., 1998, 66:531-6
[2] Barsigian et al., J. Biol. Chem., 1991, 266:22501-9
[3] Basso, M. et al. J. Neurosci. 2012, 32, 6561
Note
Intended for research use only, not for use in human, therapeutic or diagnostic applications.

News

Blog

Events