„DON“ compounds

Boc-DON-Gln-Ile-Val-OMe, Boc-DON

Quantity Unit Price Status
10 mg 400 € Available
Documents
Art. No.
B003
Synonym
tert.-Butyloxycarbonyl-(6-Diazo-5-oxonorleucinyl)-LGlutaminyl-L-Isoleucinyl-L-Valinmethylester
Molecular Formula
C28H47N7O9
Molecular Weight
625.7
Purity by HPLC
>95 % (HPLC)
Appearance
yellow solid
Solubility
100 μM in 0.1% (v/v) DMSO / aqueous buffers.
Pre-dissolve the complete 10 mg (adjust to the weight given on the vial) in 160 μL DMSO. Take e.g. 10 μL of the 100 mM stock solution and add 9990 μL buffer or assay components to obtain your final assay solution (100 μM).
DMSO stock solutions are sterile and can be stored at -20°C for at least 6 months. To avoid too many freeze-thaw cycles, we strongly recommend storage of aliquots.
Alternatively, higher concentrations of 1.5 mM in 2% (v/v) DMSO / aqueous buffers are feasible.
Application
Irreversible inhibitor of tissue transglutaminase; IC50 ~ 0.3 µM
Storage
store at -20°C, desiccate
Reference(s)
Verhaar et al., Neurochem. Int. 2011, 58:785-93
Schaertl et al., J. Biomol. Screen. 2010, 15:478-87
McConoughey et al., EMBO Mol. Med. 2010, 2:1-22
Zeugolis et al., J. Biomed. Mater. Res. 2010, 15:1310-20
Kristen et al., Circ. Res. 2008, 102:529-37
Mádi et al., Anal. Biochem. 2005, 343:256-62
Note
Intended for research use only, not for use in human, therapeutic or diagnostic applications.

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