Celiac disease products


Celiac disease affects 1% of the population and therefore is the most common chronic inflammation of the small intestine triggered by cereal gluten/gliadin uptake in genetically susceptible individuals. The gluten induced autoimmune disorder is characterized by autoantibodies to tissue transglutaminase (TG2), antibodies to deamidated gliadin and villous atrophy in the final stage.

TG2 plays a central role in celiac disease. Besides being the major autoantigen it is involved in the pathogenesis. Under certain circumstances and in distinct environments as given in the inflamed gut TG2 catalyzes deamidation of glutamine side chains in gliadin yielding glutamic acid. Deamidated gliadin is subsequently recognized by receptors of the immune system triggering celiac disease.

Related gluten induced autoimmune disorders are dermatitis herpetiformis / Morbus Duhring (autoantigen: epidermal transglutaminase, TG3).


Gluten-sensitive neurological disorders like Gluten ataxia may be accompanied by auto- antibodies to neuronal transglutaminase (TG6).
Detection of TG6-autoantibodies in human sera is possible using our ELISA-Kits E103 (anti-TG6-IgA) and E104 (anti-TG6-IgG).

New: Analytical service for measurement of TG6-autoantibodies in human serum samples

In co-operation with the medical laboratory of Prof. Dr. med. M. Kramer (board-certified clinical pathologist) in Heidelberg, Germany we provide testing services for the determination of Transglutaminase auto-antibodies in patient serum samples.

Order Sheet (English)
Bestellformular (Deutsch)

  • News  

    • Press release: Dr. Falk Pharma and Zedira announce completion of phase 1b clinical trial of ZED1227 for the treatment of celiac disease and move on to proof of concept study
    • Pressemitteilung: Dr. Falk Pharma und Zedira geben den Abschluss der Phase 1b-Studie für ZED1227 zur Zöliakie-Therapie bekannt und planen Start der Wirksamkeitsstudie
  • Blog

  • Events  

    • 17th International Celiac Disease Symposium

      08.09.2017 - 10.09.2017
      New Delhi, India

    • NLSDays 2017

      12.09.2017 - 14.09.2017
      Malmö, Sweden

    • BIO-Europe

      06.11.2017 - 08.11.2017
      Berlin, Germany

    • MEDICA

      13.11.2017 - 16.11.2017
      Düsseldorf, Germany

    • Gordon Research Conference on: Transglutaminases in Human Disease Processes

      16.06.2018 - 17.06.2018
      Les Diablerets, Switzerland