Lysine analogues- chloromethyl ketones

Already in 1981 a medicinal chemist at Bayer in Wuppertal, Germany [Gerd Reinhardt,  Ann. N.Y. Acad. Sci. 1981, 370, 836.] designed a series of direct acting Factor XIIIa blockers. According to the author the molecule combines the substrate amine architecture (Lysine co-substrate) with the chemical reactivity of the sulfhydryl reagent (active site cysteine attacking the chloromethyl ketone). The compound inhibits at least tissue transglutaminase as well.

Lysine analogues reaction machanism

Art. No.
C094 Tosyl-ε-aminopentyl-CMK
1 mg
415 €
C095 Dansyl-ε-aminopentyl-CMK
1 mg
415 €

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