Zedira’s general approach in medicine targets dysregulated transglutaminase activity in disease states.

In the human body, eight transglutaminases fulfill a broad variety of physiological functions. On the other hand, transglutaminases are involved in the pathophysiology of various disorders. Celiac disease, thrombosis, fibrosis or even cancer and such neurodegenerative diseases as Alzheimer’s, Huntington’s and Parkinson’s disease are just some examples.


Celiac Disease
Zedira’s drug candidate ZED1227 targeting dysregulated TG2 in celiac disease is currently tested in phase I clinical trials (first-in-class).
 
 
  Partnering in Drug Development
Zedira offers its proprietary drug discovery platform for partnering in drug development.
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Gluten Sensitive Neurological Disorders

Auto-antibodies specific for neuronal transglutaminase (TG6) can be measured with our proprietary ELISA-kits.

New: Analytical service for measurement of TG6-autoantibodies in human serum samples.
   
Thrombosis / Anticoagulation
Proof-of-principle for safe anticoagulation, meaning anticoagulation without increased bleeding risk using blood coagulation factor FXIIIa-blockers has recently been shown.
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  • News  

    • Press release: Dr. Falk Pharma and Zedira announce completion of phase 1b clinical trial of ZED1227 for the treatment of celiac disease and move on to proof of concept study
    • Pressemitteilung: Dr. Falk Pharma und Zedira geben den Abschluss der Phase 1b-Studie für ZED1227 zur Zöliakie-Therapie bekannt und planen Start der Wirksamkeitsstudie
  • Blog

  • Events  

    • Transglutaminases in Medicine

      03.08.2017 - 05.08.2017
      Debrecen, Hungary

    • 17th International Celiac Disease Symposium

      08.09.2017 - 10.09.2017
      New Delhi, India

    • NLSDays 2017

      12.09.2017 - 14.09.2017
      Malmö, Sweden

    • BIO-Europe

      06.11.2017 - 08.11.2017
      Berlin, Germany

    • MEDICA

      13.11.2017 - 16.11.2017
      Düsseldorf, Germany

    • Gordon Research Conference on: Transglutaminases in Human Disease Processes

      16.06.2018 - 17.06.2018
      Les Diablerets, Switzerland