D-dimers

Monoclonal antibody to D-Dimer, clone 1D2


D-Dimer: released by fibrinolysis of FXIII cross-linked fibrin

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100 µg 365 € available


Documents
Art. No. A047
Background info As the very last step of blood coagulation factor XIII (plasma transglutaminase) cross links D-domains of fibrin molecules. Clot degradation by the fibrinolytic protease plasmin then releases so called D-Dimers.
D-Dimers serve as marker for thrombotic events and the blood disease disseminated intravascular coagulation (DIC). It is an approved diagnostic marker for the exclusion of venous thromboembolism (VTE). There is growing evidence, that D-Dimer antitgen measurements may help clinicians in numerous other clinical scenarios like deep vein thrombosis (DVT), pulmonary embolism, hemolysis or even in chemotherapy (Adam et al., Blood 2009; 113:2878-87)
Host Mouse
Immunogen Human cross-linked D-Dimer
Specificity Specific for D-Dimer
Appearance Single homogenous batch, 0.2 μM filtered supplied liquid in a 20 mM carbonate buffer, pH 9.2 containing 0.1% sodium azide.
Description >80% pure mouse monoclonal antibody (Isotype IgG3), purified using anion exchange chromatography.
Application Western blot, ELISA and Collodial Gold Lateral flow Recommended as detection antibody with A046 in Sandwich Assays – Gold Conjugate lateral flow tests (capture antibody on nitrocellulose) and ELISA (Tag-HRP antibody)
Working dilutions Optimal dilutions should be determined by the end user- For Western-Blottin: 1 / 5,000 to
1 / 10,000 is a rough guideline
Storage Long term storage: < -15°C, Aliquotation is recommended in order to avoid repeated freeze thaw cycles.
Note Intended for research use only, not for use in human, therapeutic or diagnostic applications.

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