FXIII-Inhibitors

Art. No.

A108

Synonym

Ac-Asp-MA-Nle-Nle-Leu-Pro-Trp-Pro-OH ZED1301

Background info

Peptidic inhibitor containing an electrophilic Michael acceptor (MA) warhead

Molecular Formula

C53H77N9O14

Molecular Weight

1064.23

Purity by HPLC

>95 % (214 nm)

Appearance

Off-white solid

Solubility

3.50 mg/ml (3.28 mM) in PBS buffer Alternative 10 μM in 0.1% (v/v) DMSO / aqueous buffers Pre-dissolve e.g. 2.15 mg (2.02 μmol) in 202 μl DMSO - dilute e.g. 10 μl of that stock solution (10 mM) with 9990 μl aqueous buffer to obtain a 10 μM solution. DMSO stock solutions can be stored at -20°C for at least 6 months. To avoid too many freeze-thaw cycles, we strongly recommend storage of aliquots.

Application

Site specific irreversible inhibitor of plasma transglutaminase (factor XIII, FXIII) Peptidic inhibitor containing an electrophilic Michael acceptor (MA) warhead

Storage

Store at -20°C, desiccate

Reference(s)

Stieler, M. et al. Angewandte Chemie Intl. Ed. 2013, 52, 11930.

Note

INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS

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