Blood coagulation

Transglutaminase saves lives!

Blood clot formation is a vital process to prevent live threatening blood loss after injuries. The plasmatic part of blood coagulation cascade can be divided into three steps:

  • Cascade leading to activation of prothrombin (T091)
  • Fibrinogen (F004) activation by thrombin (T056, T090) and fibrin aggregation (soft blood clot)
  • Factor XIII activation by thrombin and cross-linking of fibrin fibers as well as covalent decoration with antifibrinolytics

Plasma transglutaminase factor XIII plays an essential role in blood clot formation. In addition, factor XIII is unique in this process, as all the other enzymes involved are proteases. Factor XIII renders the blood clot stiff and resistant against fibrinolytic degradation. Due to the fact that it is the only transglutaminase in the cascade, it offers the opportunity for a unique modulation of coagulation and in consequence promising approaches e.g. to prophylaxis of thrombotic events in risk patients.

An excellent historical account on FXIII in blood clotting is given by Laszlo Lorand: Factor XIII and the clotting of fibrinogen: from basic research to medicine. J. Thromb. Haemost. 2005, 3:1337-48.

Novel compounds developed by medicinal chemists at Zedira guide the way to small molecules targeting selectively coagulation factor XIII. In contrast to the currently available therapies, factor XIII blocking allows formation of a weak fibrin clot. This prevents bleeding lowering the risk of lifethreatening complications.

Products

  • Zedira offers a huge portfolio of reliable specialist transglutaminase related products meant to catalyze research and development, both in academia and industry.

News  

  • Zedira publication: Microbial Transglutaminase Used in Bread Preparation at Standard Bakery Concentrations Does Not Increase Immunodetectable Amounts of Deamidated Gliadin
  • Pressemitteilung: Dr. Falk Pharma und Zedira geben den Abschluss der Phase 1b-Studie für ZED1227 zur Zöliakie-Therapie bekannt und planen Start der Wirksamkeitsstudie
  • Press release: Dr. Falk Pharma and Zedira announce completion of phase 1b clinical trial of ZED1227 for the treatment of celiac disease and move on to proof of concept study
  • Press Release: Dr. Falk Pharma GmbH and Zedira enter a phase 1b clinical trial for a celiac disease drug
  • Zedira publication: Microbial transglutaminase has a lower deamidation preference than human tissue transglutaminase on a celiac disease relevant wheat gliadin T-cell epitope
  • Press release: Additional subsidy funding for clinical development of a celiac disease drug
  • Pressemitteilung: Zusätzliche Fördermittel für die klinische Entwicklung eines Zöliakie-Medikamentes
  • Press Release: Cooperation between Zedira and Cardiff University - Transglutaminase 6 is the focus of new research into ataxia
  • Press Release: Dr. Falk Pharma and Zedira enter phase I clinical trials for a celiac disease drug
  • Press release: Zedira receives further funding to develop Factor XIIIa-blockers for safe anticoagulation

Blog  

Events  

  • MEDICA

    13.11.2017 - 16.11.2017
    Düsseldorf, Germany

  • Gordon Research Conference on: Transglutaminases in Human Disease Processes

    16.06.2018 - 17.06.2018
    Les Diablerets, Switzerland