Celiac Disease Products

Celiac disease affects 1% of the population and therefore is the most common chronic inflammation of the small intestine triggered by cereal gluten/gliadin uptake in genetically susceptible individuals. The gluten-induced autoimmune disorder is characterized by autoantibodies to tissue transglutaminase (TG2), antibodies to deamidated gliadin, and villous atrophy in the final stage.

TG2 plays a central role in celiac disease. Besides being the primary autoantigen, it is involved in the pathogenesis. Under certain circumstances and in distinct environments such as in the inflamed gut, TG2 catalyzes deamidation of glutamine side chains in gliadin yielding glutamic acid. Deamidated gliadin is subsequently recognized by receptors of the immune system triggering celiac disease.

Related gluten-induced autoimmune disorders are dermatitis herpetiformis / Morbus Duhring (autoantigen: epidermal transglutaminase, TG3).

Gluten-sensitive neurological disorders like gluten ataxia may be accompanied by auto- antibodies to neuronal transglutaminase (TG6). Its detection is part of the “Guidelines on the diagnosis and management of the progressive ataxias” (de Silva et al., 2019).
Detection of TG6-autoantibodies in human sera is possible using our ELISA Kits E103 (anti-TG6-IgA) and E104 (anti-TG6-IgG).

Analytical service for measurement of TG6-autoantibodies in human serum samples

In co-operation with the medical laboratory of Prof. Dr. med. M. Kramer (board-certified clinical pathologist) in Heidelberg, Germany, we provide testing services for the determination of transglutaminase autoantibodies in patient serum samples.

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