Inhibitors



Transglutaminases are involved in a multitude of physiological processes. One way to explore these processes is to use specific inhibitors. In addition to naturally occurring inhibitors such as the protein tridegin, rationally designed synthetic, small molecule inhibitors such as Z-DON (Z006) or T101 will be of immeasurable help to scientists wishing to decipher the enigmatic roles of individual transglutaminases.   

In the following section, Zedira’s range of transglutaminase inhibitors is introduced with a special focus on their respective mechanisms of action:   


“DON” compounds (6-diazo-5-oxo-L-norleucine containing peptides)

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2-[(2-oxo-propyl)thio]imidazolium derivatives  

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Naturally occurring inhibitors


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Michael acceptor peptidomimetics

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Keillor Inhibitors (Acrylamide derivatives) 

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Unknown mode of inhibiton



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