Transglutaminases are involved in a multitude of physiological processes. One way to explore these processes is to use specific
inhibitors. In addition to naturally occurring
inhibitors such as the protein tridegin, rationally designed synthetic, small molecule inhibitors such as
Z-DON (
Z006) will be of immeasurable help to scientists wishing to decipher the enigmatic roles of individual
transglutaminases.
In the following section,
Zedira’s range of
transglutaminase inhibitors is introduced with a special focus on their respective mechanism of action:
“DON” compounds (6-diazo-5-oxo-L-norleucine containing peptides)
read more 2-[(2-oxo-propyl)thio]imidazolium derivatives
read more Keillor Inhibitors (Acrylamide derivatives)
read more