Microbial (Pro)TGase

EC 2.3.2.13; Protein-glutamine-γ-glutamyltransferase

Andracon^TM is a brand for high quality microbial transglutaminase:
• Recombinantly produced in E. coli
• Ultra-pure and highly active
• Batch to batch consistent quality
• License free
• Produced according to an SOP in an ISO9001:2015 certified environment
Andracon^TM (Microbial Transglutaminase, MTG) catalyzes the acyl transfer reaction between γ-carboxyamide groups of peptide-bound glutamine residues and a variety or primary amines.
Therefore, Andracon^TM can be used to attach primary-amine coupled functional markers like biotin, fluorescent dyes, click chemistry reagents or cytotoxins to proteins, e.g. antibodies.
Essentially, Andracon^TM is used for the production of antibody drug conjugates (ADCs).

38334.0 Da (theoretical, activated MTG with N-terminal sequence: FRAPDSDDR...)

Recombinantly produced in E. coli. Gene derived from Streptomyces mobaraensis.

> 30 U/mg

(Frozen) liquid

50 mM HEPES pH 7.4

Labeling, immobilisation, conjugation, and modification of proteins.

Store at -80°C. Store working aliquots undiluted.
If storage at -80°C is not possible, storage at ≤ -20°C is recommended.

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INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.