1. August 2019

Transglutaminases in Translation - Special issue in Analytical Biochemistry

Dear Colleagues in academia and industry,

Driven by clinical programs, the transglutaminase researcher community is in an exciting and promising phase. At the same time we have to face the very sad news of losing two esteemed members of our community:

Already on December 6th 2018 Laszlo Lorand, one of the pioneers in factor XIII and transglutaminase research, passed away at the age of 95.

Very recently, on August 19th the unexpected and untimely passing of Soichi Kojima shocked the entire transglutaminase community. Soichi will always be remembered as an excellent scientist passionate about tissue transglutaminase and as a friend to many of us.

We would like to respect both, Laszlo’s and Soichi’s legacy to the transglutaminase field and dedicate the upcoming Special Issue in Analytical Biochemistry 'in memoriam' to their contributions to the advancement of our field.

This Special Issue in Analytical Biochemistry is going to appear in Spring of 2020:

“Transglutaminases in Translation – Novel Tools and Methods Impacting on Diagnostics and Therapeutics”

Since the discovery of transglutaminases by H. Waelsch and coworkers in 1957, basic research has created fundamental knowledge regarding this very special class of enzymes, providing the basis for translation to diagnostics and medicine and even to technical applications.

 Auto-antibodies to tissue transglutaminase (TG2) provide a diagnostic standard in celiac disease.
 The first TG2-blocker is currently being evaluated in celiac disease patients in a phase 2a study.
 An anti-TG2 monoclonal antibody for the treatment of a fibrotic kidney injury has just entered phase 1/2 trials.
 Coagulation FXIII is a diagnostic marker in blood coagulation and a target for drug discovery.
 Microbial transglutaminase (MTG), which has been used since the 1990s in the food industry, is now being tested as a component of medical devices.
 Enzymatic conjugation by MTG is a state-of-the-art method for the production of site specifically conjugated antibody drug conjugates with a defined drug-to-antibody ratio.

This special issue of Analytical Biochemistry is dedicated to providing insight into 1) the latest basic research in the field, and 2) research already in translation for diagnostic, therapeutic and technical purposes. The content is anticipated to range from transglutaminase biochemistry, including structural aspects, assays and novel methods, as well as to (patho)physiological roles and pathways. Therapeutic and diagnostic approaches, technical applications in medicinal products and drug manufacturing will also be included in order to provide an up-to-date overview on “Transglutaminases in Translation”. Finally original work, reviews, or a mixture are welcome.

We heartily invite renowned experts in their respective field to contribute to this special issue. Please notice that manuscripts in special issues are published once they are accepted. Authors will not have to wait for the last submission to be accepted to have a volume and page numbers assigned to their article.

In order to submit a paper for this Special Issue, please sign into the EVISE site for AB via this link:

Select the drop down menu and choose your Special Issue title “TGases in Translation”. Then choose the article type from the drop down list, add the details and submit your article.

The submissions are open from 1-Aug-2019, and the final submission deadline is 30-Nov-2019.

We are looking forward to receiving your paper submissions.
Please contact us for any questions.

Best regards,
Ralf Pasternack
Martin Hils
Guest editors for Analytical Biochemistry
Ralf and Martin