Factor XIII

Human blood coagulation Factor XIII-A2

(hFXIII, A subunit, rec. produced in human embryonic kidney cells)
Quantity Unit Price Status
100 µg 450 € Available
Art. No.
Recombinant Fibrin stabilizing factor, protein-glutamine-γ-glutamyltransferase
Molecular Weight
83 kDa (monomer); 166 kDa (homodimer)
Recombinantly produced in human embryonic kidney cells (HEK-293F)
White lyophilized solid.
Recombinant human Factor XIII is a homodimer (A2) composed by two chains held together by non-covalent bonds. It is N-terminally fused to a hexahistidine-tag. After activation of the zymogen by Thrombin and Ca2+ to its active form (Factor XIIIa), Factor XIIIa catalyzes the formation of covalent bridges (ε-(γ-glutamyl) lysine bonds) between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is insoluble and resistant to lysis.
Add the volume of water specified in the certificate of analysis under aliquotation to the vial of lyophilized powder. Rotate vial gently until solid dissolves. After reconstitution the solution should be stored frozen in undiluted working aliquots. For short term storage keep cooled on ice.
FXIIIa catalyzes acyl transfer reactions from glutamine residues in proteins or peptides to primary amines, e. g. the formation of ε-(γ-glutamyl) lysine bonds between proteins by transferring the acyl group of a peptide-bound glutamine residue to the primary amino group of a peptide-bound lysine residue.
Store at -80°C.
If storage at -80°C is not possible, storage at ≤ -20°C is recommended. While no formal stability data are available at -20°C, according to our overall experience stability is still given.
Upon reconstitution, store undiluted working aliquots preferably at -80°C (if not possible at ≤ -20°C, see comment above). Storage of diluted aliquots may result in severe activity loss. Avoid repeated freezing and thawing.
Delivery at ambient temperature is possible
Intended for research use only, not for use in human, therapeutic or diagnostic applications.