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| Factor XIII |
| FXIII-Inhibitors |
| Fibrin aggregation and clotting |
| FXIII Activity Assays |
| Fibrin clot degradation |
| Antibodies |
FXIII Activity Assays
FXIII-Assay Substance,
Abz-NE(CAD-DNP)EQVSPLTLLK-OH Art. No.
A101
Synonym
FXIII-Assay Substance, fluorescent Abz-NE(CAD-DNP)EQVSPLTLLK-OH trifluoroacetate
Background info
Also suitable for TG1, TG2, TG3 and TG6
Molecular Formula
C78H122N20O25 (free base)
Molecular Weight
1739.92 (free base)*
Purity by HPLC
>95 % (214 nm)
Appearance
Yellow solid
Solubility
50 μM in 0.1% (v/v) DMSO / aqueous buffers (calculated with M.W. 1853.95). Pre-dissolve e.g. 10 mg (5.39 μmol) in 108 μl DMSO - dilute e.g. 10 μl of that stock solution (50 mM) with 9990 μl aqueous buffer to obtain a 50 μM solution. DMSO stock solutions are sterile and can be stored at -20°C for at least 6 months. To avoid too many freeze-thaw cycles, we strongly recommend storage of aliquots.
Application
Kinetic measurement of transglutaminases (FXIII, TG1, TG2, TG3, and TG6)
Storage
Store at -20°C, desiccate
Reference(s)
Oertel, K. et al. Anal. Biochem. 2007, 367, 152. Dodt, J. et al. Anal. Biochem. 2013, 439, 145. Berny‐Lang, M.A. et al. J. Am. Heart Assoc. 2013, 2, e000026. Schroeder, V. et al. Br. J. Haematol. 2015, 168, 757. de Jager, M. et al. Neuropathol. Appl. Neurobiol. 2016, 42, 255. Király, R. et al. Amino Acids 2016, 48, 31. van der Wildt, B. et al. Nucl. Med. Biol. 2016, 43, 232. Dodt, J. et al. Br. J. Haematol. 2016, 172, 452. Chrobok, N.L. et al. PLoS ONE 2018, 13, e0209522. Akbar, A. et al. J. Med. Chem. 2017, 60, 7910-7927. Singh, S. et al. Int. J. Mol. Sci. 2019, 20, 2682. Gates, E. et al. Molecules 2023, 28,1634. Hamedani, N.S. et al. J. Clin. Med. 2021, 10, 677.
Note
The quantification of the TFA counter ion content is performed by using a 19F NMR method according to Little et al. (J. Pharm. Biomed. Anal. 2007, 43, 1324), based on an internal standard. INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS
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