FXIII-Inhibitors

Art. No.

T101

Synonym

L-682.777, SU732

Molecular Formula

C10H17ClN2OS (free cation: C10H17N2OS+)

Molecular Weight

248.77 (free cation: 213.32)

Purity by HPLC

>95 % (214 nm)

Appearance

Off white solid

Solubility

50 mM in aqueous buffers Dissolve e.g. 5.0 mg in 402 µl PBS buffer to obtain a 50 mM solution or: 50 µM in 0.1% (v/v) DMSO / aqueous buffers. Pre-dissolve e.g. 10.0 mg in 804 µl DMSO (50 mM). Take e.g. 10 µl of the 50 mM stock solution - dilute by adding 9990 µl buffer or assay components to obtain your final assay solution (50 μM). DMSO stock solutions are sterile and can be stored at -20°C for at least 6 months. To avoid too many freeze-thaw cycles, we strongly recommend storage of aliquots.

Application

Inhibitor for transglutaminase

Storage

Store at -20°C, desiccate

Reference(s)

Freund, K.F. et al. Biochemistry 1994, 33, 10109. Lorand, L. et al. Exp. Eye Res. 1998, 66, 531. Dale, G.L. et al. Nature 2002, 415, 175. Dodt, J. et al. Anal. Biochem. 2013, 439, 145. v.d. Akker J. et al. PLoS One 2011, 6, e23067. Matlung, H.L. et al. Atherosclerosis 2010, 213, 77. Barsigan C. et al., J. Biol. Chem. 1991, 266, 22501. Katt, P.W. et al. Mol. Pharmaceutics 2015, 12, 46-55. Aleman, M.M. et al. J. Clin. Invest. 2014, 124, 3590. Aleman, M.M. et al. PLoS ONE 2015, 10, e0124448.Kattula, S. et al. Blood Adv. 2018, 2, 25-35. Macrae, F.L. et al. Clin Invest. 2018, 128, 3356-3368.

Note

INTENDED FOR RESEARCH USE ONLY, NOT FOR USE IN HUMAN, THERAPEUTIC OR DIAGNOSTIC APPLICATIONS.

Related Products

A101: FXIII-Assay Substance,
T002: Human tissue transglutaminase
T027: Human blood coagulation Factor XIII-A₂