FXIII-Inhibitors

1,3-Dimethyl-4,5-diphenyl-2-[(2-oxopropyl)thio]imidazolium trifluorosulfonic acid salt



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Art. No. D004
Synonym "L-683.685"; 1,3-Dimethyl-2-(2-oxopropylthio)-4,5-diphenyl-1H-imidazol-3-ium trifluoromethanesulfonate
Molecular Formula C21H21F3N2O4S2 (free cation: C20H21N2OS+)
Molecular Weight 486.53 (free cation: 337.46)
Purity > 95% (NMR)
Appearance off white solid
Solubility Pre-dissolve e.g. 2.02 mg in 207.6 μl DMSO to obtain a 20 mM stock solution - dilute 20 μl of that stock solution with 980 μl buffer (e.g. 50 mM TRIS-HCl, pH 7.5) to obtain a 400 μM solution
Application Inhibitior for transglutaminase.
The molecule was developed to block coagulation factor XIIIa, however the compound inhibits tissue transglutaminase as well. Both enzymes are inhibited with an IC50 of about 0.35 μM.
Storage Store at -20°C
Reference(s) Lorand et al., Exp. Eye Res., 1998, 66:531-6
Barsigian et al., J. Biol. Chem., 1991, 266:22501-9
Note Intended for research use only, not for use in human, therapeutic or diagnostic applications.

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