Specificity of A014 was determined with human transglutaminases (TG1 – TG7, FXIII) and TG2 of different species.
A014 has no cross reactivity to TG1, TG6 and TG7 and very slight cross reactivity to TG3, TG4, TG5 and FXIII.
A014 also recognizes TG2 form various species, although at a lower signal intetnsity. Note: A014 also detects dog TG2.
The epitopes the polyclonal antibody to human TG2 binds to were determined using PEPperCHIP® Transglutaminase Microarray (
P111).
A014 recognizes the epitopes Y
149LDSE
153, D
242NNYGDGVSP
251, N
318EFGEIQG
325, Q
348PGYEG
353, Q
355ALDPTPQEK
364, D
438ITHT
442, P
446EGSSEEREAFT
457, F
492AHITNNTAEE
502, L
629TEEQ
633, E
637IPDPVEAG
645For more information klick here:
Poster presentation at GRC, 2016 (Girona, Spain)