Gliadin peptides derived from Triticum aestivum (wheat) are the main immunotoxic antigens in celiac disease. They are a substrates for tissue transglutaminase, which specifically deamidates glutamine residues within these peptides, and therefore strongly increases their immunogenicity (Dørum S. et al., J. Proteome Res. 2009; 8:1748-55).
We offer a set of fusion proteins that carry the different native and deamidated peptide sequences that facilitate the analysis of antibodies found in celiac disease related samples. See also section: Celiac Disease Products