Zedira is a privately held, clinical-stage biopharmaceutical company specialized in transglutaminase.
Zedira’s drug candidate ZED12271 was the first transglutaminase blocker ever tested in clinical trials.
The peptidomimetic compound showed proof-of-concept in a phase 2a study in celiac disease patients. In addition, ZED1227 has a placebo-like safety profile.
For the first time, a transglutaminase is clinically validated as a druggable target.
Zedira is conducting several drug discovery programs targeting dysregulated human transglutaminases. The company established a pipeline of small-molecule drug candidates adapted to specific indications. Please refer to the Medicine section for comprehensive information.
Our pipeline is available on request (contact@zedira.com).
Managing Partners and Scientific Advisory Board
Martin Hils and Ralf Pasternack,
managing partners of Zedira, founded the company in 2007.
“Transglutaminase is our inspiration – improving health and creating value is our mission.“
The Scientific Advisory Board consists of Uwe Gerlach, Matthias Löhr and Rüdiger Herrmann, distinguished experts who bring deep knowledge and experience from academia and industry. Their guidance supports our mission to drive innovation and ensure scientific excellence across all areas of our work.
Specialists for Transglutaminases
Zedira is the global brand for specialty reagents for research & development as well as diagnostics in the transglutaminase field. More than 300 unique and high-quality products help accelerate transglutaminase-related research – both in academia and industry.
Scientists from academia and industry (including several of the top 15 pharmaceutical companies) benefit from Zedira’s cutting-edge products and customized services.
Zedira’s recombinant, ultra-pure, and highly active microbial transglutaminase (MTG) is a unique tool to generate homogenous antibody drug conjugates (ADCs). Today, ADCs manufactured with Zedira’s Andracon™ are entering clinical trials. Find detailed information about Andracon™ in our MTG-Handbook.
Zedira products are made in Germany by Zedira’s highly skilled professionals in an ISO9001:2015 certified facility. The excellent feedback from our customers motivates us daily to provide our high-quality transglutaminase specialty reagents to researchers world wide.
Diagnostics
Zedira’s ISO9001:2015 certified facility enables the production of high-quality diagnostic antigens in the celiac field, including TG2, TG3, TG6, and DGPs (deamidated gliadin peptides). Moreover, Zedira’s proprietary anti-TG6-ELISA allows the detection of autoantibodies to neuronal transglutaminase (TG6), a novel marker in the field of gluten-related neurological disorders.
1 Büchold C, Hils M, Gerlach U, Weber J, Pelzer C, Heil A, Aeschlimann D, Pasternack R. Features of ZED1227: The First-In-Class Tissue Transglutaminase Inhibitor Undergoing Clinical Evaluation for the Treatment of Celiac Disease. Cells. 2022; 11(10):1667. https://doi.org/10.3390/cells11101667
Besuch des Bundesministers für Wirtschaft und Klimaschutz Dr. Robert Habeck bei der Zedira 
Discover Our New Catalogue Edition and Dive into the World of Transglutaminases! 
Successful ISO9001:2015 recertification 
Dr. Falk Pharma and Zedira announce successful completion of the phase 2a proof-of-concept study of ZED1227 for the treatment of Celiac Disease 
Dr. Falk Pharma und Zedira verkünden den erfolgreichen Abschluss der Phase 2a-Studie mit ZED1227 zur Behandlung von Zöliakie 
Reversibly acting transglutaminase 2 inhibitors: drug candidates for the treatment of fibrosis 
Transcriptomic analysis of the efficacy of TG2-inhibitor trials and human intestinal organoids modelling Celiac disease pathogenesis 
Transglutaminase antibodies and neurological manifestations of gluten sensitivity 
Design of Oral FXIIIa Blockers as Safer Anticoagulants Mission Impossible? 
Microbial transglutaminase (MTG) enables efficient and site-specific conjugation to native antibodies without the need of antibody engineering 
Tridegin as FXIIIa inhibitor 
Microbial transglutaminase: from discovery to market 
Tissue transglutaminase inhibitors 
Tissue transglutaminase in Alzheimers Disease 
Factor XIIIa: novel target for anticoagulation? 
Microbial transglutaminase for site-specific protein conjugation